Latest research
The latest research papers
Newest material first. A dated divider separates papers added in the latest update from earlier landmark studies, so you can see what is new at a glance.
Updated
Entries were located through PubMed's public interface, arXiv's API and the journals' own sites. Each title links to the publisher's page through its DOI or to the arXiv record. Preprints have not been peer reviewed.
Added 15 October 2026 New
Journal of the American Medical Association and JAMA Neurology
- JAMA Neurology
Examines whether the leading blood biomarker performs equally across racial and ethnic groups in people without symptoms.
- JAMA Neurology
A randomised trial showing that giving clinicians blood-biomarker results earlier improved diagnostic certainty and changed management.
- JAMA Neurology
Which blood markers best track the spread of tau into the cortex, the stage most closely tied to symptoms.
- Journal of the American Medical Association
In 2,684 cognitively normal adults, each standard-deviation rise in p-tau217 raised the risk of progression by 38 percent; the highest group had a 38 percent absolute risk over five years.
- JAMA Network Open
Pregnancy hypertension as an early marker of later dementia risk in women.
- Journal of the American Medical Association
A readable summary of the 2026 Alzheimer's Association International Conference.
Science
- Science
Why women carry two-thirds of Alzheimer's cases, and what hormonal change does to the brain.
- Science
Microglia, complement and the immune side of neurodegeneration.
- Science
Tau's damage to mitochondria, a direct link between the disease protein and brain metabolism.
- Science
How the three-dimensional folding of DNA inside individual brain cells changes in Alzheimer's.
- Science
The shift of the drug pipeline from amyloid toward tau.
- Science
A mechanism by which the immune system prunes synapses in the adult brain.
Neurology, Nature Medicine and other journals
- Neurology
Midlife hypertension raised dementia risk at every level of genetic risk; treating blood pressure helps everyone.
- Neurology
How heart-metabolic and Alzheimer's genetic risk combine across ancestries.
- Neurology
- Neurology
- Nature Medicine
The negative result of the semaglutide trials in early Alzheimer's.
- Nature Medicine
The ELAD trial of a GLP-1 drug; see the metabolism page for what it found.
- Diabetes Care
arXiv preprints (AI and genetics)
- arXiv
- arXiv
- arXiv
- arXiv
- arXiv
Landmark studies, 2024 to 2025
- EHJ
539,478 people; no continuous association between Lp(a) and dementia, with small isoforms linked to higher Alzheimer's risk.
- Journal of the American Medical Association
2,111 older adults; the structured programme improved cognition more than the self-guided one, in APOE ε4 carriers and non-carriers alike.
- Nature Medicine
- Nature Communications
Machine learning on 41,686 genomes recovered every known locus and found six new ones, but did not beat classical methods for individual prediction.
- Annals of Neurology
Lower B12, even within the normal range, was linked to slower nerve conduction and more white-matter damage.
- Circulation
- Alzheimer's Research & Therapy
APOE plus a polygenic score reaches an AUC of 0.72 to 0.76, the realistic ceiling for genetic prediction today.
- Lancet
The fourteen modifiable risk factors, now including high LDL cholesterol and untreated vision loss.
- Nature Medicine
Where to keep looking
- PubMed, sorted by most recent, for the search behind this page.
- arXiv q-bio.GN (Genomics) and an arXiv search for "Alzheimer".
- Science research articles and JAMA Neurology.
- Alzforum papers, which summarises new studies for non-specialists.