23andMe and the main Alzheimer's indicator
What the company reports today, what APOE ε4 does and does not mean, and why the FDA-authorised report checks one gene only.
Brain · DNA · Heart
Alzheimer's Information – Understanding the links between your brain, your heart and your genes
A source of clear and concise information on Alzheimer's and Dementia as it relates to brain health, heart health, and your genes.
We list Clinical Trials in both the USA and EU, the latest research from top journals such as Pubmed, arXiv, Science and the Journal of the American Medical Association, other authoritative sources that deal with Alzheimer's, and our own Advisor.
We also allow you to create an account, login, tell us about yourself, and subscribe to our newsletter.
Research will be updated weekly, and Trials will be updated monthly. The Newsletter will be sent monthly.
Updated
This site is educational. It does not diagnose, treat, or replace advice from a licensed clinician, and it never collects, stores or analyses genetic data.
Four connected topics
Where the evidence points
Roughly 45 percent of dementia cases are linked to risk factors that can be changed, and most of them run through the heart, the blood vessels and metabolism. Each topic page explains the science, what you can do, and what is still uncertain.
Brain health
The fourteen modifiable risk factors, what the 2025 US POINTER trial showed about lifestyle, sleep and hearing, and how blood tests are changing early detection.
Read about brain health →Heart health
Why blood pressure in midlife matters most, what LDL and lipoprotein(a) have to do with dementia, and the heart-brain measures worth tracking.
Read about heart health →Brain health and metabolism
Vitamin B12, folate and homocysteine, blood sugar and insulin, thyroid function, and the mixed results from GLP-1 drugs in Alzheimer's trials.
Read about metabolism →Genetics of heart and brain
APOE, familial hypercholesterolaemia, lipoprotein(a), and the MTHFR and B12 pathway: the genes that affect both organs and what consumer tests show.
Read about genetics →Reference pages
Tests, trials and the latest research
Clinical trials in the US and EU
Prevention and early-treatment trials that are recruiting or fully enrolled, with registry links and how to search for one near you.
Latest research
Recent papers from PubMed, arXiv, Science and Journal of the American Medical Association, newest first, with a divider separating new material from earlier landmark studies.
Other websites
Established, non-commercial organisations that offer advice and information on brain health, heart health, nutrition and genetics.
How this site handles your information
Nothing on this site asks for or accepts genetic data. The APOE explanations work from the result you can already read in your 23andMe account, and the Advisor stores nothing. That is a deliberate choice: in the United States, software that analyses a DNA file and reports Alzheimer's risk is a regulated medical device, and holding genetic data brings obligations under state genetic-privacy laws. An educational site crosses neither line.